Candida vaginitis: virulence, host response and vaccine prospects
نویسندگان
چکیده
منابع مشابه
Candida vaginitis.
Candida vaginitis Other than the dermatophytic mycoses, Candida vaginitis is the most common fungal disease in the United Kingdom, described by Morton and Rashid (1977) as a near epidemic. Almost all the known facts about it are enumerative or descriptive and little is known of the factors affecting the pathogenesis, recrudescence, or recurrence of the mycosis. The facts do not disclose the psy...
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1 Department of Oral and Craniofacial Biology, Dental School, Louisiana State University Health Sciences Center, New Orleans, Louisiana, United States of America, 2 Department of Prosthodontics, Dental School, Louisiana State University Health Sciences Center, New Orleans, Louisiana, United States of America, 3 Department of Microbiology, Immunology, and Parasitology, School of Medicine, Louisi...
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In Saccharomyces cerevisiae, the vacuolar protein sorting complexes Vps51/52/53/54 and Vps15/30/34/38 are essential for efficient endosome-to-Golgi complex retrograde transport. Here we investigated the function of Vps15 and Vps51, representative members of these complexes, in the stress resistance, host cell interactions, and virulence of Candida albicans. We found that C. albicans vps15Δ/Δ an...
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Candida albicans Ssa1 and Ssa2 are members of the HSP70 family of heat shock proteins that are expressed on the cell surface and function as receptors for antimicrobial peptides such as histatins. We investigated the role of Ssa1 and Ssa2 in mediating pathogenic host cell interactions and virulence. A C. albicans ssa1Δ/Δ mutant had attenuated virulence in murine models of disseminated and oroph...
متن کاملA murine model of Candida glabrata vaginitis.
Vaginal Candida glabrata infections have increased significantly in recent years and are particularly common in women with uncontrolled diabetes mellitus. Efforts to understand the pathogenesis and treatment of this infection have been hindered by the lack of experimental animal models. Before onset of hyperglycemia, nonobese diabetic (NOD) mice inoculated intravaginally with clinical C. glabra...
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ژورنال
عنوان ژورنال: Medical Mycology
سال: 2018
ISSN: 1369-3786,1460-2709
DOI: 10.1093/mmy/myx139